产品货号：
Z36677
中文名称：
RNF20抗体
英文名称：
Anti-RNF20 Antibody (Clone#1594CT552.128.36)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RNF20 Antibody (Clone#1594CT552.128.36) |
| 指标别名 | BRE1;BRE1 A;BRE1A;hBRE1;KIAA2779;ring finger protein 20;RNF20 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | RNF20 |
| 克隆号 | 1594CT552.128.36 |
| 抗体来源 | Mouse |
| 免疫原 | This RNF20 antibody is generated from a mouse immunized with a recombinant protein of human RNF20. |
| 计算分子量 | 114kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1).H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me,respectively).It thereby plays a central role inb histone code and gene regulation.The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B;reports about the cooperation with UBE2E1/UBCH are contradictory.Required for transcriptional activation of Hox genes.Recruited to the MDM2 promoter,probably by being recruited by p53/TP53,and thereby acts as a transcriptional coactivator.Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. |
| Uniprot ID | Q5VTR2 |
相关搜索：RNF20抗体，RNF20单抗，Anti-RNF20 Antibody (Clone#1594CT552.128.36)